Nutrition View All Articles. The latest studies have shown that a high consumption of red meat is associated with an increased risk of colorectal [ 66 ] and gastric cancer [ 67 ]. Table 5. National Center for Biotechnology Information, U. Resveratrol, a compound found in red wine, may have anti-inflammatory effects. Serum uric acid levels and multiple health outcomes: Umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies. Moore, F. Results 3. Mitjavila M. Liu X.
To evaluate the long-term effects of a Mediterranean diet MeDiet intervention on the plasma concentrations of inflammatory and plaque stability-related molecules in elderly people at high risk for cardiovascular disease. Design and Setting. Long-term adherence to MeDiet decreases the plasma concentrations of inflammatory biomarkers related to different steps of atheroma plaque development in elderly persons at high cardiovascular risk. Atherosclerosis is a low-grade chronic inflammatory disorder of the vessel wall that involves the accumulation of lipids, especially low-density lipoproteins LDL, in the intima. Oxidation of LDL particles oxLDL leads to macrophage activation and recruitment of monocytes, neutrophils, T-, and B-lymphocytes [ 1 ] in the vascular wall which induces the formation of atheroma plaque [ 2 ]. The first step of the process is the recruitment of monocytes including endothelial adhesion molecules, such as P- and E-selectins rolling process, and subsequently, vascular cell adhesion molecule-1 VCAM-1 and intercellular adhesion molecule-1 ICAM-1 migration process [ 3 — 5 ]. Increases in some of these inflammatory biomarkers have been associated with an increased risk of cardiovascular events in patients with coronary artery disease, and thus a large number of new inflammatory biomarkers are currently being studied as possible mediators of inflammation [ 9 ]. The Mediterranean diet MeDiet is characterized by a high intake of extra virgin olive oil EVOO, nuts, legumes, vegetables, fruit, fish, and whole grain products. The main nutrients of this dietary pattern are fiber, monounsaturated fatty acids MUFA, n-3 polyunsaturated fatty acid n-3 PUFA, vitamin C, vitamin E, and carotenoids, and all of which are associated with lower inflammation against saturated fatty acids SFA or trans fatty acids TFA and high-glucose and high-fat meals which may induce postprandial inflammation and, hence, are considered as proinflammatory factors [ 10 ].
The immune system in atherosclerosis. Tressserra-Rimbau et al. The effect of MD experiences a decrease in adiponectin response related to the male sex. Get Started. Kris-Etherton P. How are you changing the future?